Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic disorder of the peripheral nerves characterized by gradually increasing loss of sensation and weakness associated with loss of reflexes. It is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. Symptoms often include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and is considered the chronic counterpart of that acute disease.
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