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What to Know About Subcutaneous Immunoglobulin (SCIg)

Learn about Subcutaenous Immunoglobulin (SCIg) therapy for managing primary immune deficiencies as well as some autoimmune and neurological conditions.
Learn about Subcutaenous Immunoglobulin (SCIg) therapy for managing primary immune deficiencies as well as some autoimmune and neurological conditions.

Subcutaneous immunoglobulin (SCIg) therapy is a medical treatment used to manage rare and chronic primary immune deficiencies, certain autoimmune conditions, and some neurological disorders. SCIg provides patients with a vital source of antibodies to enhance their immune system’s ability to fight infections and maintain overall health. This article will explore the benefits of SCIg, uses, and administration process of SCIg to help patients, caregivers, and healthcare professionals understand its role in treating these conditions. 

 

What is Subcutaneous Immunoglobulin (SCIg)? 

SCIg is a form of immunoglobulin therapy in which purified antibodies are injected under the skin (subcutaneously) rather than into a vein. Immunoglobulins are essential proteins that help fight infections caused by bacteria and viruses. When the body can’t produce enough antibodies on its own, SCIg therapy provides them as replacement therapy to improve immune function. By delivering the necessary antibodies, SCIg helps patients fight infections more effectively and supports overall immune health. 

Administration of SCIg Treatments 

SCIg is administered through a subcutaneous injection, meaning immunoglobulin is injected beneath the skin rather than directly into a vein. These injections are typically given in the fatty tissue of the abdomen, thigh, or upper arm. After receiving proper training from an experienced infusion nurse, many patients are able to administer SCIg at home on their own. Each infusion typically requires 3-4 needles, depending on the dosage. Subcutaneous infusions can be scheduled in smaller doses a few times a week, or larger doses once a week or every other week, depending on the patient’s specific treatment plan. 

 

Diseases Treated with SCIg Therapy 

SCIg infusion is a potential treatment option for patients with immunodeficiencies, autoimmune diseases, and neurological conditions that affect the immune system, including: 

  • Primary Immunodeficiencies (PID) 
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) 

 

Benefits of SCIg Therapy 

SCIg therapy offers a range of benefits for patients with rare and chronic health conditions, including: 

  • Immune Globulin Replacement: SCIg replaces the missing or dysfunctional antibodies in patients who have an immune deficiency. The goal of SCIg is to reduce the frequency, severity, and potential complications of repeated infections. 
  • Convenient Self Administration at Home: With proper training from an infusion nurse, many patients can conveniently administer SCIg therapy at home, reducing the need for frequent nurse visits. 
  • Minimal Side Effects: SCIg therapy usually causes fewer side effects that affect the whole body as compared to IVIg therapy. This can make it a comfortable option for long-term treatments. 
  • Improved Quality of Life: SCIg may allow patients to experience fewer infections, better immune health, and increased energy levels to improve their overall quality of life. 

 

SCIg Therapy Side Effects 

As with any medical treatment, SCIg treatments may come with some mild side effects. Common side effects include temporary pain, redness, or swelling at the injection site. Some patients may experience mild headaches or fatigue as well. Less common symptoms include fever or chills. It’s important to consult with a healthcare provider about any side effects or concerns to make sure they are managed with proper care. 

 

In-Home SCIg Therapy with CSI Pharmacy 

At CSI Pharmacy, we specialize in IVIg and SCIg infusion therapies for patients with immunodeficiencies, autoimmune, and other rare or chronic conditions. Our nationwide team of nurses is committed to delivering expert, compassionate care in the comfort of your home. Alongside our dedicated pharmacy, insurance & reimbursement, and intake teams, we ensure that you have the support you need every step of the way. If you’re looking for an IVIg or SCIg partner, let us help make the process seamless and stress-free. 

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