Immunoglobulin therapy, also known as Ig therapy, has become an effective treatment for a variety of autoimmune and immune deficiency conditions. Whether you are considering treatment options for yourself or a loved one, understanding the different types of immunoglobulin therapies, IVIg (Intravenous Immunoglobulin) and SCIg (Subcutaneous Immunoglobulin), is important for making an informed decision. We’ll explain the differences between IVIg and SCIg and highlight important points to think about.
What is Immunoglobulin (Ig) Therapy?
Immunoglobulins are proteins that naturally occur in your immune system and are found in donated human plasma. These proteins are antibodies that play a vital role in defending the body against harmful pathogens (germs), such as bacteria and viruses.
Ig therapy involves infusions of healthy immunoglobulins to treat conditions such as primary immunodeficiency, autoimmune diseases, and some neurological disorders.
In some patients, the immune system doesn’t produce enough immunoglobulins (immune deficiency) so the Ig therapy replaces what is missing in the body. At higher doses for auto-immune conditions, Ig therapy helps to regulate the immune system.
Treatment goals may include reducing infections for immune deficiency, and for autoimmune conditions, decreasing the disease symptoms and stopping the disease from getting worse.
Getting to Know IVIg (Intravenous Immunoglobulin)
IVIg is one of the most common forms of Ig therapy. During an IVIg infusion treatment, immunoglobulins are injected directly into the bloodstream through an intravenous (IV) infusion. IVIg infusions are administered by a trained infusion nurse every 3-4 weeks in the comfort of your home or a clinic setting. IVIg infusions can take anywhere from a few hours to several hours, depending on the dose and the patient’s needs.
Getting to Know SCIg (Subcutaneous Immunoglobulin)
SCIg infusion therapy is another type of Ig therapy that’s administered into the fatty tissue under the skin (subcutaneously). SCIg can be administered at home by the patient themselves, after receiving proper training from an experienced infusion nurse. SCIg requires a few needles for each infusion (typically 3-4 needles) and has more frequent administration compared to IVIg. The subcutaneous infusions can be done in smaller doses a few days a week or larger doses once weekly or every other week.
Comparing IVIg & SCIg Infusions
IVIg and SCIg infusions are both potential treatment options for patients with immunodeficiencies, autoimmune diseases, and neurological conditions including:
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- Primary Immunodeficiencies (PID)
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- Myasthenia Gravis (MG)
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- Dermatomyositis
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- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
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- Multifocal Motor Neuropathy (MMN)
The main differences between these two administration methods of Immunoglobulin are shown in the table below.
Factors to Consider |
IVIg Infusion |
SCIg Infusion |
Administration |
Intravenous (IV), given by a trained infusion nurse | Subcutaneous (under the skin), self-administered after required training |
Frequency of Treatment |
Every 3-4 weeks | Daily, weekly, or every other week |
Infusion Location |
Can be administered by a home infusion nurse or in a clinic setting | Can be done at home via self-administration after proper training |
Needle Sticks |
1 needle stick per treatment | Multiple needle sticks needed depending on the dose |
IVIg vs SCIg: Which Option is Right for You?
Choosing between IVIg and SCIg depends on several factors, including your specific medical condition, treatment goals, lifestyle, and the recommendations of your healthcare team. Both are effective options for treating a variety of autoimmune and immune deficiency conditions. Consult with your healthcare provider to determine which treatment method is best fit for your needs and treatment goals.
IVIg & SCIg Home Infusion Therapy with CSI Pharmacy
At CSI Pharmacy, we specialize in IVIg and SCIg infusion therapies for patients with immunodeficiencies, autoimmune, and other rare or chronic conditions. Our nationwide team of nurses is committed to delivering expert, compassionate care in the comfort of your home. Alongside our dedicated pharmacy, insurance & reimbursement, and intake teams, we ensure that you have the support you need every step of the way. If you’re looking for an IVIg or SCIg partner, let us help make the process seamless and stress-free.
